Genetic testing for breast cancer

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An estimated 0. For some people, though, the chances of having a BRCA gene mutation are much higher. Genes are inherited, which is why knowing your family history is important when determining breast cancer risks.

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April 9,by NCI Staff. Many women diagnosed with ovarian and breast cancers are not receiving tests for inherited genetic mutations, according to a new study. Tests for inherited genetic mutations can provide women diagnosed with ovarian or breast cancer with important information that can have implications for family members and potentially guide treatment decisions and longer-term screening for second cancers.

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Genetic testing gives people the chance to learn if their breast cancer or family history of breast cancer is due to an inherited gene mutation. This section provides information on genetic counseling and testing for gene mutations that increase breast cancer risk. It also has information on inherited gene mutations and other related topics, such as the benefits and risks of testing, direct-to-consumer genetic testing and testing for multiple high-risk gene mutations panel testing.

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Abnormal PALB2 genes are suspected to raise the risk of ovarian cancer, but larger studies need to confirm that risk. Men with these mutations have an increased risk of breast cancer, especially if the BRCA2 gene is affected, and possibly of prostate cancer. Many inherited cases of breast cancer have been associated with mutations in these three genes. But when these genes contain the mutations that are passed from generation to generation, they do not function normally and breast cancer risk increases.

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Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving. Genetic testing has improved since then and new tests can find mutations that were previously missed by older tests. The following gene mutations have been linked with an increased risk for breast cancer.

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When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer. People who have inherited mutations in BRCA1 and BRCA2 tend to develop breast and ovarian cancers at younger ages than people who do not have these mutations.

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Back to Health A to Z. BRCA genes are not the only cancer risk genes. Researchers recently identified more than new gene variants associated with an increased risk of breast, prostate and ovarian cancer.

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After a routine mammogram in revealed a tumor in her right breast, Wendy Mayer was diagnosed with invasive lobular carcinoma. Fortunately, it had not spread. But her mother, her grandmother, and a cousin had all had breast cancer, so on the advice of her doctors, Mayer underwent genetic testing. Mutations in these genes are linked to an increased risk for breast and ovarian cancers.

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The choice to have genetic counseling and proceed with genetic testing is one to be taken seriously and with some caution. Though it can sound simple to be tested, there are many things to consider before making this decision. Our physicians and nurses will help guide you through the entire process so you understand the pros and cons of genetic testing.

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Women who have inherited mutations in these genes are at an increased risk of developing breast cancer and ovarian cancer compared with the general population. The BRCA gene test is offered only to people who are likely to have an inherited mutation based on personal or family history, or who have a specific type of breast cancer. The BRCA gene test isn't routinely performed on women at average risk of breast and ovarian cancers. If you do, your result is positive and your doctor can help you understand your cancer risk.


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